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A method of measuring the enzymatic activity of a luciferase includes contacting a luminogenic protein, such as a luciferase, with a protected luminophore to form a composition; and detecting light produced from the composition. The protected luminophore provides increased stability and improved signal-to-background ratios relative to the corresponding unmodified coelenterazine.
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C07K CPC COOPERATIVE PATENT CLASSIFICATION C CHEMISTRY; METALLURGY (NOTES omitted) CHEMISTRY C07 ORGANIC CHEMISTRY (such compounds as the oxides, sulfides, or …
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The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme ('DP-IV inhibitors') and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes.
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